Basket trials and umbrella trials were created to help researchers study how tumors respond to targeted therapies.
Basket trials, also known as bucket trials, enroll patients whose tumors have a specific genetic mutation, regardless of where their cancer started.
Umbrella trials enroll patients with one type of cancer and have many different treatment arms. Patients are assigned to a specific arm based on the biomarkers seen in their tumor.
The articles below explain the goals of these trials. They also discuss potential challenges and concerns.
You can find all the basket trials enrolling breast cancer patients from BreastCancerTrials.org
Understand Basket and Umbrella Trials
- Animated Video from Roche: Illuminating Ideas: Innovative Clinical Trial Design
- Dr. Polly Presentation: Basket and Umbrella Trial Designs in Oncology
Basket and Umbrella Trials: Past and Now
- Living Beyond Breast Cancer: A Tisket, A Tasket, Trials Now Come in Baskets
- Pharmacy Times: Basket Studies: An Innovative Approach to Clinical Trials
Basket Trials: Advantages, Challenges and Opportunities
- Cancer Therapy Advisor: Basket Trials: Advantages and Limitations
- eCancer News: Basket Trials and Umbrella Trials: Challenges and Opportunities
Current Basket Trials:
- eCancer News: Results of SUMMIT Basket Trial in HER2+ Breast Cancer
- Contemp Clin Trials Commun.: NCI MATCH: A Basket/Umbrella Combo
- ASCO: NCI TAPUR: A Multi-Basket Study
- BreastCancerTrials.org: all basket trials enrolling breast cancer patients