What Are “Lines of Therapy”? - Metastatic Breast Cancer Trial Talk

Inside Clinical Trials

“Lines of therapy” is the term used to describe the order in which different therapies are given to people as their disease progresses. 

In practice, doctors may choose a patient’s next line of therapy based on established treatment guidelines, recently published clinical trial results or even the person’s unique life situation. For clinical trials, lines of therapy — including how many and which therapies were given — are often included in the enrollment requirements.  Some trials even study if an already-approved therapy should be given as an earlier line of therapy or a later line of therapy than what is currently recommended.

The following articles define lines of therapy, discuss how each line of therapy is chosen, and explain current MBC treatment guidelines. 

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