Update on Oral SERDs and New Types of Hormone Therapies - Metastatic Breast Cancer Trial Talk

Research News

People with estrogen receptor-positive (ER+) MBC are generally treated with hormone therapy. Hormone therapy prevents the body from making estrogen or blocks the ability of cancer cells to respond to estrogen. 

Several types of hormone therapy are approved for MBC, and others are being tested in clinical trials. Resistance to hormone therapy, which is when the therapy stops working, is common. Clinical trials are also testing combinations of hormone therapy drugs and other types of drugs such as CDK4/6 inhibitors and PI3K inhibitors. These new drugs and drug combinations are being tested to address resistance. 

One type of hormone therapy is called selective estrogen receptor degraders (SERDs). Importantly, new SERDs that are taken by mouth (called oral SERDs) are being tested. Oral SERDs can be taken at home and do not require a doctor’s visit to receive an injection, which helps improve quality of life. Other types of hormone therapy are also being studied in trials. Read below to find out more about oral SERDs and other types of hormone therapy, as well as find trials studying experimental hormone therapy drugs.

Oral SERDs
Other Types of Hormone Therapy
MBC Clinical Trials

Last Modified on June 3, 2024



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