Clinical trials for TNBC, HER2 positive, and other subtypes of metastatic (stage IV) breast cancer have been added to BreastCancerTrials.org (BCT) in the last month. These clinical trials can also be found on Metastatic Trial Search (MTS).

Stage IV Triple Negative Breast Cancer (TNBC)

• Chemotherapy Alone or with Alpelisib for Advanced Triple Negative Breast Cancer with a PIK3CA Mutation or PTEN Loss
• Immunotherapy Before Surgery for Triple Negative Brain Metastases that are PD-L1 Positive

Stage IV HR Positive (ER+ and/or PR+) Breast Cancer

• The Experimental Anti-Estrogen Therapy GDC-9545 for Advanced ER+, HER2- Breast Cancer 
• Experimental Anti-Estrogen Therapy OP-1250 in Advanced, Hormone Positive, HER2 Negative Breast Cancer
• Immunotherapy FP-1305 for Advanced Estrogen Receptor Positive Breast Cancer

Stage IV HER2 Positive Breast Cancer 

• Anti-HER2 Targeted Therapy GQ1001 in Advanced HER2 Positive Breast Cancer
• Tucatinib and Trastuzumab Deruxtecan for Advanced HER2 Positive Breast Cancer

Stage IV Breast Cancer (Other)

• PARP Inhibitor AMXI-5001 for Advanced Breast Cancer
• Using MRIs to Screen for Brain Metastases in Advanced Breast Cancer
• An Experimental PET/CT Scan to Find PARP-Expressing Tumor Cells
• Using PET/CT Scans to See How Breast Cancer That Has Spread to the Bones is Responding to Therapy
• An Experimental Targeted Therapy For Advanced Breast Cancer

Last Modified on November 2, 2020