Clinical trials for TNBC, HER2 positive, and other subtypes of metastatic (stage IV) breast cancer have been added to BreastCancerTrials.org (BCT) in the last month. These clinical trials can also be found on Metastatic Trial Search (MTS).

Stage IV Triple Negative (TNBC) Trials

• Targeted Therapy AL101 for Advanced Triple Negative or ER-Low Breast Cancer that Tests Positive for Notch Activation
• Targeted Therapy MGC018 Alone or with Immunotherapy MGA012 in Advanced Triple Negative Breast Cancer

Stage IV HR Positive (ER+ and/or PR+) Trials

• Sacituzumab Govitecan With or Without Pembrolizumab for Advanced HR+, HER2- Breast Cancer that is PD-L1+
• Lasofoxifene and Abemaciclib for Women with Advanced ER+, HER2- Breast Cancer with an ESR1 Mutation
• GDC-9545 or Letrozole with Palbociclib for Advanced ER+, HER2- Breast Cancer

Other Stage IV Trials

• Targeted Therapy GNX102 in Advanced Breast Cancer
• Cryotherapy (Freezing) and Immunotherapies for Breast Cancer that has Spread to the Skin
• HER3 Inhibitor Seribantumab for People with Advanced Breast Cancer that is NRG1 Gene Fusion Positive
• Copanlisib and Fulvestrant for Metastatic Breast Cancer with a PIK3CA or PTEN Mutation
• Immunotherapy and BT8009 for Metastatic Breast Cancer that Expresses Nectin-4
• Radioactive Targeted Therapy for Advanced Neuroendocrine Breast Cancer

Last Modified on April 9, 2021